Drug interactions
Insulin degludec-insulin aspart + Niacin
Severity: Moderate
Insulin degludec-insulin aspart and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Niacin, especially at lipid-lowering doses, can cause insulin resistance and raise blood glucose, reducing insulin effectiveness. Insulin requirements may increase.
What this interaction means in plain words
Insulin degludec-insulin aspart and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Niacin belongs to Cardiovascular.
Why it happens
Niacin induces insulin resistance and increases hepatic glucose output, opposing insulin action.
What to do
Monitor blood glucose after starting or increasing niacin and adjust the insulin dose as needed. Reassess the need for niacin if glycemic control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Niacin?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin, especially at lipid-lowering doses, can cause insulin resistance and raise blood glucose, reducing insulin effectiveness. Insulin requirements may increase.
How serious is the interaction between Insulin degludec-insulin aspart and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or increasing niacin and adjust the insulin dose as needed. Reassess the need for niacin if glycemic control deteriorates.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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