Drug interactions
Insulin degludec-insulin aspart + Pasireotide
Severity: Moderate
Insulin degludec-insulin aspart and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide commonly causes hyperglycemia by suppressing insulin and incretin secretion, so it tends to oppose insulin's effect. Patients with diabetes often need intensified glucose-lowering therapy, and insulin requirements may fall again if pasireotide is stopped.
What this interaction means in plain words
Insulin degludec-insulin aspart and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide inhibits insulin, GLP-1 and GIP secretion, antagonizing the glucose-lowering action of insulin.
What to do
Monitor blood glucose closely when starting pasireotide and adjust insulin upward as needed. Reassess insulin dose when pasireotide is stopped or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Pasireotide?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide commonly causes hyperglycemia by suppressing insulin and incretin secretion, so it tends to oppose insulin's effect. Patients with diabetes often need intensified glucose-lowering therapy, and insulin requirements may fall again if pasireotide is stopped.
How serious is the interaction between Insulin degludec-insulin aspart and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting pasireotide and adjust insulin upward as needed. Reassess insulin dose when pasireotide is stopped or reduced.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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