Drug interactions
Insulin degludec-insulin aspart + Phenelzine
Severity: Moderate
Insulin degludec-insulin aspart and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the hypoglycemic effect of insulin and have been associated with episodes of hypoglycemia. This can be significant in patients with tight glucose control.
What this interaction means in plain words
Insulin degludec-insulin aspart and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin secretion or sensitivity and impair counterregulatory responses, adding to insulin effect.
What to do
Monitor glucose closely when starting or stopping the MAOI and reduce insulin doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Phenelzine?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can potentiate the hypoglycemic effect of insulin and have been associated with episodes of hypoglycemia. This can be significant in patients with tight glucose control.
How serious is the interaction between Insulin degludec-insulin aspart and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting or stopping the MAOI and reduce insulin doses if hypoglycemia occurs.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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