Drug interactions
Insulin degludec-insulin aspart + Prednisolone
Severity: Moderate
Insulin degludec-insulin aspart and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone causes hyperglycemia and insulin resistance, reducing the effect of insulin. Insulin requirements often rise during therapy and fall after the steroid is reduced.
What this interaction means in plain words
Insulin degludec-insulin aspart and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and reduce peripheral insulin sensitivity, antagonizing insulin.
What to do
Monitor glucose more often, especially postprandially, and titrate insulin during steroid therapy. Reduce insulin as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Prednisolone?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone causes hyperglycemia and insulin resistance, reducing the effect of insulin. Insulin requirements often rise during therapy and fall after the steroid is reduced.
How serious is the interaction between Insulin degludec-insulin aspart and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often, especially postprandially, and titrate insulin during steroid therapy. Reduce insulin as the steroid is tapered.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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