Drug interactions
Insulin degludec / insulin aspart + Prochlorperazine
Severity: Minor
Insulin degludec / insulin aspart and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can raise blood glucose, which may reduce the effect of insulin in people with diabetes. The effect is generally modest and variable between patients.
What this interaction means in plain words
Insulin degludec / insulin aspart and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenothiazines may impair insulin secretion and sensitivity, though the mechanism is not fully established.
What to do
Monitor blood glucose more frequently when prochlorperazine is started, changed or stopped. Adjust the insulin dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Prochlorperazine?
MediHelp rates the interaction as minor. Insulin degludec / insulin aspart and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can raise blood glucose, which may reduce the effect of insulin in people with diabetes. The effect is generally modest and variable between patients.
How serious is the interaction between Insulin degludec / insulin aspart and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when prochlorperazine is started, changed or stopped. Adjust the insulin dose if control worsens.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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