Drug interactions
Insulin degludec / insulin aspart + Progesterone
Severity: Minor
Insulin degludec / insulin aspart and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestogens can reduce glucose tolerance and insulin sensitivity, which may weaken the glucose-lowering effect of insulin. Higher insulin requirements may result.
What this interaction means in plain words
Insulin degludec / insulin aspart and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism through progestogen-related insulin resistance.
What to do
Monitor blood glucose when starting, stopping or changing progesterone and adjust the insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Progesterone?
MediHelp rates the interaction as minor. Insulin degludec / insulin aspart and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestogens can reduce glucose tolerance and insulin sensitivity, which may weaken the glucose-lowering effect of insulin. Higher insulin requirements may result.
How serious is the interaction between Insulin degludec / insulin aspart and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing progesterone and adjust the insulin dose as needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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