Drug interactions
Insulin degludec-insulin aspart + Somapacitan
Severity: Moderate
Insulin degludec-insulin aspart and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity, so patients with diabetes may need higher insulin doses after somapacitan is started. Glycemic control may worsen if doses are not adjusted.
What this interaction means in plain words
Insulin degludec-insulin aspart and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone has counter-regulatory effects that promote insulin resistance and raise blood glucose.
What to do
Monitor blood glucose after starting or increasing somapacitan and adjust insulin doses accordingly. Reassess if the growth hormone dose is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Somapacitan?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity, so patients with diabetes may need higher insulin doses after somapacitan is started. Glycemic control may worsen if doses are not adjusted.
How serious is the interaction between Insulin degludec-insulin aspart and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or increasing somapacitan and adjust insulin doses accordingly. Reassess if the growth hormone dose is reduced.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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