Drug interactions
Insulin degludec-insulin aspart + Somatrogon
Severity: Moderate
Insulin degludec-insulin aspart and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a growth hormone analog, reduces insulin sensitivity and may raise insulin requirements in patients with diabetes. Glycemic control may deteriorate without dose changes.
What this interaction means in plain words
Insulin degludec-insulin aspart and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone has counter-regulatory effects that promote insulin resistance and raise blood glucose.
What to do
Monitor blood glucose when starting or adjusting somatrogon and increase insulin doses as needed. Reduce insulin again if growth hormone is stopped or lowered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Somatrogon?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a growth hormone analog, reduces insulin sensitivity and may raise insulin requirements in patients with diabetes. Glycemic control may deteriorate without dose changes.
How serious is the interaction between Insulin degludec-insulin aspart and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting somatrogon and increase insulin doses as needed. Reduce insulin again if growth hormone is stopped or lowered.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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