Drug interactions
Insulin degludec-liraglutide + Miglitol
Severity: Moderate
Insulin degludec-liraglutide and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol slows carbohydrate absorption and lowers postprandial glucose, adding to the effect of insulin and liraglutide. Hypoglycemia must be treated with glucose rather than sucrose, since miglitol impairs sucrose breakdown.
What this interaction means in plain words
Insulin degludec-liraglutide and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Alpha-glucosidase inhibition adds to insulin and GLP-1 glucose lowering.
What to do
Monitor glucose and reduce insulin dose if hypoglycemia occurs; treat hypoglycemia with oral glucose (dextrose), not table sugar.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Miglitol?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miglitol slows carbohydrate absorption and lowers postprandial glucose, adding to the effect of insulin and liraglutide. Hypoglycemia must be treated with glucose rather than sucrose, since miglitol impairs sucrose breakdown.
How serious is the interaction between Insulin degludec-liraglutide and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce insulin dose if hypoglycemia occurs; treat hypoglycemia with oral glucose (dextrose), not table sugar.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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