Drug interactions
Insulin degludec-liraglutide + Pegvisomant
Severity: Moderate
Insulin degludec-liraglutide and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant lowers IGF-1 and growth hormone action, which can improve insulin sensitivity and glucose tolerance. In patients on insulin degludec/liraglutide this can cause hypoglycemia, and reduced doses of antidiabetic drugs may be needed.
What this interaction means in plain words
Insulin degludec-liraglutide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Blocking growth hormone receptors reduces GH-mediated insulin resistance, giving an additive glucose-lowering effect.
What to do
Monitor blood glucose when pegvisomant is started. Reduce the insulin degludec dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Pegvisomant?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant lowers IGF-1 and growth hormone action, which can improve insulin sensitivity and glucose tolerance. In patients on insulin degludec/liraglutide this can cause hypoglycemia, and reduced doses of antidiabetic drugs may be needed.
How serious is the interaction between Insulin degludec-liraglutide and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pegvisomant is started. Reduce the insulin degludec dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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