Drug interactions
Insulin degludec-liraglutide + Pentoxifylline
Severity: Minor
Insulin degludec-liraglutide and Pentoxifylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline has been reported to enhance the glucose-lowering effect of insulin and other antidiabetic drugs in some patients. When added to insulin degludec-liraglutide, this may lead to hypoglycemia that was not anticipated from the existing regimen.
What this interaction means in plain words
Insulin degludec-liraglutide and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-liraglutide belongs to Endocrine; Pentoxifylline belongs to Cardiovascular.
Why it happens
Possible additive glucose-lowering effect; the mechanism is not firmly established.
What to do
Monitor blood glucose when pentoxifylline is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-liraglutide and Pentoxifylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Pentoxifylline?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentoxifylline has been reported to enhance the glucose-lowering effect of insulin and other antidiabetic drugs in some patients. When added to insulin degludec-liraglutide, this may lead to hypoglycemia that was not anticipated from the existing regimen.
How serious is the interaction between Insulin degludec-liraglutide and Pentoxifylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pentoxifylline is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
