Drug interactions
Insulin degludec-liraglutide + Risperidone
Severity: Moderate
Insulin degludec-liraglutide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause weight gain and impair glucose regulation, which may reduce the effect of insulin degludec-liraglutide. Diabetic patients may need adjustment of their regimen after starting it.
What this interaction means in plain words
Insulin degludec-liraglutide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics can induce insulin resistance and weight gain, opposing antidiabetic therapy.
What to do
Monitor glucose and HbA1c after starting or changing risperidone. Increase the antidiabetic dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Risperidone?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause weight gain and impair glucose regulation, which may reduce the effect of insulin degludec-liraglutide. Diabetic patients may need adjustment of their regimen after starting it.
How serious is the interaction between Insulin degludec-liraglutide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or changing risperidone. Increase the antidiabetic dose as required.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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