Drug interactions
Insulin degludec-liraglutide + Sotalol
Severity: Moderate
Insulin degludec-liraglutide and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol, a non-selective beta-blocker, may prolong hypoglycemia and mask its warning symptoms in insulin-treated patients. It may also worsen glycemic control through reduced insulin release.
What this interaction means in plain words
Insulin degludec-liraglutide and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade impairs glycogenolysis and masks adrenergic hypoglycemia symptoms.
What to do
Monitor blood glucose more frequently after starting sotalol. Counsel patients about masked hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Insulin degludec-liraglutide with Sotalol?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol, a non-selective beta-blocker, may prolong hypoglycemia and mask its warning symptoms in insulin-treated patients. It may also worsen glycemic control through reduced insulin release.
How serious is the interaction between Insulin degludec-liraglutide and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting sotalol. Counsel patients about masked hypoglycemia symptoms.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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