Drug interactions
Insulin glargine + Procarbazine
Severity: Moderate
Insulin glargine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting properties, and MAO inhibitors have been reported to enhance the glucose-lowering effect of insulin. This may increase the risk of hypoglycemia in patients on basal insulin.
What this interaction means in plain words
Insulin glargine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition may enhance insulin-mediated hypoglycemia, although the mechanism is not firmly established.
What to do
Monitor blood glucose more frequently when procarbazine is started or stopped. Reduce the insulin glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Insulin glargine with Procarbazine?
MediHelp rates the interaction as moderate. Insulin glargine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has monoamine oxidase inhibiting properties, and MAO inhibitors have been reported to enhance the glucose-lowering effect of insulin. This may increase the risk of hypoglycemia in patients on basal insulin.
How serious is the interaction between Insulin glargine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when procarbazine is started or stopped. Reduce the insulin glargine dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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