Drug interactions
Insulin glargine + Sulphasalazine
Severity: Minor
Insulin glargine and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Large salicylate doses can lower blood glucose, but the salicylate exposure from sulfasalazine is low. Sulfonamides can rarely cause hypoglycemia, so an additive effect is possible but unlikely.
What this interaction means in plain words
Insulin glargine and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Theoretical additive glucose lowering from salicylate or sulfonamide effects.
What to do
Counsel patients on hypoglycemia symptoms and check glucose when starting or stopping sulfasalazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Sulphasalazine?
MediHelp rates the interaction as minor. Insulin glargine and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Large salicylate doses can lower blood glucose, but the salicylate exposure from sulfasalazine is low. Sulfonamides can rarely cause hypoglycemia, so an additive effect is possible but unlikely.
How serious is the interaction between Insulin glargine and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on hypoglycemia symptoms and check glucose when starting or stopping sulfasalazine.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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