Drug interactions
Insulin glargine + Tolazamide
Severity: Moderate
Insulin glargine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sulfonylurea with insulin produces additive glucose lowering and raises the risk of significant hypoglycemia. The risk is higher in elderly patients and those with renal impairment.
What this interaction means in plain words
Insulin glargine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of insulin secretagogue-driven insulin release and exogenous insulin.
What to do
Monitor blood glucose closely and reduce the sulfonylurea or insulin dose when hypoglycemia occurs or when starting the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Insulin glargine with Tolazamide?
MediHelp rates the interaction as moderate. Insulin glargine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sulfonylurea with insulin produces additive glucose lowering and raises the risk of significant hypoglycemia. The risk is higher in elderly patients and those with renal impairment.
How serious is the interaction between Insulin glargine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the sulfonylurea or insulin dose when hypoglycemia occurs or when starting the combination.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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