Drug interactions
Insulin glargine + Tranylcypromine
Severity: Moderate
Insulin glargine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors can enhance the blood glucose-lowering effect of insulin. This may lead to more frequent or more severe hypoglycemia in patients with diabetes who start or stop tranylcypromine.
What this interaction means in plain words
Insulin glargine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibitors are thought to augment insulin sensitivity and glucose lowering, but the exact mechanism is not firmly established.
What to do
Monitor blood glucose more frequently when tranylcypromine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Tranylcypromine?
MediHelp rates the interaction as moderate. Insulin glargine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors can enhance the blood glucose-lowering effect of insulin. This may lead to more frequent or more severe hypoglycemia in patients with diabetes who start or stop tranylcypromine.
How serious is the interaction between Insulin glargine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when tranylcypromine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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