Drug interactions
Insulin glargine-lixisenatide + Lopinavir
Severity: Moderate
Insulin glargine-lixisenatide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glucose-lowering effect of insulin glargine and lixisenatide.
What this interaction means in plain words
Insulin glargine-lixisenatide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair insulin-mediated glucose uptake, causing insulin resistance.
What to do
Monitor blood glucose when starting or changing lopinavir and increase antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Lopinavir?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glucose-lowering effect of insulin glargine and lixisenatide.
How serious is the interaction between Insulin glargine-lixisenatide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing lopinavir and increase antidiabetic doses as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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