Drug interactions
Insulin glargine-lixisenatide + Miglitol
Severity: Moderate
Insulin glargine-lixisenatide and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol adds to the glucose-lowering effect of insulin and lixisenatide and can raise hypoglycemia risk. Because miglitol delays carbohydrate absorption, oral sugar may not correct hypoglycemia quickly.
What this interaction means in plain words
Insulin glargine-lixisenatide and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Additive glucose lowering; alpha-glucosidase inhibition slows carbohydrate absorption.
What to do
Treat hypoglycemia with glucose (dextrose) rather than sucrose or complex carbohydrates. Monitor blood glucose and adjust insulin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Miglitol?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miglitol adds to the glucose-lowering effect of insulin and lixisenatide and can raise hypoglycemia risk. Because miglitol delays carbohydrate absorption, oral sugar may not correct hypoglycemia quickly.
How serious is the interaction between Insulin glargine-lixisenatide and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Treat hypoglycemia with glucose (dextrose) rather than sucrose or complex carbohydrates. Monitor blood glucose and adjust insulin as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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