Drug interactions
Insulin glargine-lixisenatide + Trazodone
Severity: Minor
Insulin glargine-lixisenatide and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants such as trazodone have occasionally been linked to altered glucose control and enhanced glucose lowering in patients taking antidiabetic drugs. The evidence is weak and the effect is usually small.
What this interaction means in plain words
Insulin glargine-lixisenatide and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
The mechanism is not established; effects on insulin sensitivity may be additive.
What to do
Monitor blood glucose when trazodone is started or stopped and adjust the antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Trazodone?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants such as trazodone have occasionally been linked to altered glucose control and enhanced glucose lowering in patients taking antidiabetic drugs. The evidence is weak and the effect is usually small.
How serious is the interaction between Insulin glargine-lixisenatide and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trazodone is started or stopped and adjust the antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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