Drug interactions
Insulin glulisine + Linagliptin
Severity: Moderate
Insulin glulisine and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to insulin improves glycemic control but can increase the risk of hypoglycemia. The risk is mainly related to the insulin component.
What this interaction means in plain words
Insulin glulisine and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering through DPP-4 inhibition, which raises incretin levels and enhances glucose-dependent insulin secretion alongside exogenous insulin.
What to do
Monitor blood glucose and consider reducing the insulin dose when linagliptin is started if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin glulisine with Linagliptin?
MediHelp rates the interaction as moderate. Insulin glulisine and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to insulin improves glycemic control but can increase the risk of hypoglycemia. The risk is mainly related to the insulin component.
How serious is the interaction between Insulin glulisine and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider reducing the insulin dose when linagliptin is started if hypoglycemia occurs.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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