Drug interactions
Insulin glulisine + Lopinavir
Severity: Moderate
Insulin glulisine and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors are associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of insulin. Patients with diabetes may need higher insulin doses or may develop worsening glycemic control.
What this interaction means in plain words
Insulin glulisine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Pharmacodynamic antagonism: protease inhibitors induce peripheral insulin resistance and may impair insulin secretion.
What to do
Monitor blood glucose regularly after starting or changing lopinavir therapy. Titrate insulin glulisine upward as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin glulisine and Lopinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin glulisine
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Insulin glulisine with Lopinavir?
MediHelp rates the interaction as moderate. Insulin glulisine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors are associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of insulin. Patients with diabetes may need higher insulin doses or may develop worsening glycemic control.
How serious is the interaction between Insulin glulisine and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after starting or changing lopinavir therapy. Titrate insulin glulisine upward as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
