Drug interactions
Insulin glulisine + Pegvisomant
Severity: Moderate
Insulin glulisine and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action, which improves insulin sensitivity in acromegaly. Diabetic patients on insulin have needed lower doses after starting it, and hypoglycemia can occur.
What this interaction means in plain words
Insulin glulisine and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism reduces insulin resistance and so enhances insulin effect.
What to do
Monitor blood glucose closely after pegvisomant is started or the dose changed. Reduce the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Insulin glulisine with Pegvisomant?
MediHelp rates the interaction as moderate. Insulin glulisine and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action, which improves insulin sensitivity in acromegaly. Diabetic patients on insulin have needed lower doses after starting it, and hypoglycemia can occur.
How serious is the interaction between Insulin glulisine and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after pegvisomant is started or the dose changed. Reduce the insulin dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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