Drug interactions
Insulin glulisine + Risperidone
Severity: Moderate
Insulin glulisine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone may cause hyperglycemia and insulin resistance, which can counteract the effect of mealtime insulin glulisine. Patients may need higher insulin doses to maintain control.
What this interaction means in plain words
Insulin glulisine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: atypical antipsychotics can induce insulin resistance and impair glucose regulation.
What to do
Check blood glucose more often when risperidone is started or the dose is changed, and titrate insulin glulisine to the readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Risperidone?
MediHelp rates the interaction as moderate. Insulin glulisine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone may cause hyperglycemia and insulin resistance, which can counteract the effect of mealtime insulin glulisine. Patients may need higher insulin doses to maintain control.
How serious is the interaction between Insulin glulisine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when risperidone is started or the dose is changed, and titrate insulin glulisine to the readings.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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