Drug interactions
Insulin isophane protamine human + Linagliptin
Severity: Minor
Insulin isophane protamine human and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to insulin improves control but can increase hypoglycemia risk modestly because both lower glucose. The risk is lower than with sulfonylureas.
What this interaction means in plain words
Insulin isophane protamine human and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin isophane protamine human belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering through DPP-4 inhibition raising incretin levels plus exogenous insulin.
What to do
Monitor glucose when starting linagliptin and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Linagliptin?
MediHelp rates the interaction as minor. Insulin isophane protamine human and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Linagliptin added to insulin improves control but can increase hypoglycemia risk modestly because both lower glucose. The risk is lower than with sulfonylureas.
How serious is the interaction between Insulin isophane protamine human and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting linagliptin and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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