Drug interactions
Interferon beta 1a + Ozanimod
Severity: Moderate
Interferon beta 1a and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod reduces circulating lymphocytes, and interferon beta has immunomodulatory effects, so combined use may add to immune suppression and infection risk. Both are used in multiple sclerosis, but combination is not an established strategy.
What this interaction means in plain words
Interferon beta 1a and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Interferon beta 1a belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive immunomodulation through lymphocyte sequestration by ozanimod and interferon effects.
What to do
Avoid planned co-therapy; when switching, monitor lymphocyte counts and infections, and allow for the persistent effect of ozanimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Interferon beta 1a
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Interferon beta 1a with Ozanimod?
MediHelp rates the interaction as moderate. Interferon beta 1a and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod reduces circulating lymphocytes, and interferon beta has immunomodulatory effects, so combined use may add to immune suppression and infection risk. Both are used in multiple sclerosis, but combination is not an established strategy.
How serious is the interaction between Interferon beta 1a and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid planned co-therapy; when switching, monitor lymphocyte counts and infections, and allow for the persistent effect of ozanimod.
What other medicines interact with Interferon beta 1a?
MediHelp also lists interactions of Interferon beta 1a with, for example, Deferiprone, Etrasimod, Hydroxycarbamide. The full list is on the Interferon beta 1a page.
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