Drug interactions
Iobenguane i + Lisdexamfetamine
Severity: Major
Iobenguane i and Lisdexamfetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is converted to dextroamphetamine, which interferes with uptake of iobenguane into adrenergic nerve terminals and tumor cells. This can reduce tracer uptake and give false-negative imaging or reduced therapeutic effect.
What this interaction means in plain words
Iobenguane i and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
The active amphetamine competes for the norepinephrine transporter and blocks iobenguane uptake.
What to do
Withhold lisdexamfetamine for several half-lives before iobenguane administration, in line with product labeling, if clinically feasible, and confirm timing with nuclear medicine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Iobenguane i with Lisdexamfetamine?
MediHelp rates the interaction as major. Iobenguane i and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisdexamfetamine is converted to dextroamphetamine, which interferes with uptake of iobenguane into adrenergic nerve terminals and tumor cells. This can reduce tracer uptake and give false-negative imaging or reduced therapeutic effect.
How serious is the interaction between Iobenguane i and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold lisdexamfetamine for several half-lives before iobenguane administration, in line with product labeling, if clinically feasible, and confirm timing with nuclear medicine.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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