Drug interactions
Ipratropium + Loxapine
Severity: Moderate
Ipratropium and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine has moderate anticholinergic activity, so ipratropium may add to dry mouth, constipation, urinary retention and blurred vision. Inhaled loxapine is bronchospastic, and ipratropium would not be expected to prevent that, so respiratory status should be watched with the inhaled form.
What this interaction means in plain words
Ipratropium and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic symptoms, especially in older patients. Reassess the need for both agents if constipation or urinary retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Ipratropium with Loxapine?
MediHelp rates the interaction as moderate. Ipratropium and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine has moderate anticholinergic activity, so ipratropium may add to dry mouth, constipation, urinary retention and blurred vision. Inhaled loxapine is bronchospastic, and ipratropium would not be expected to prevent that, so respiratory status should be watched with the inhaled form.
How serious is the interaction between Ipratropium and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially in older patients. Reassess the need for both agents if constipation or urinary retention develops.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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