Drug interactions
Ipratropium + Maprotiline
Severity: Moderate
Ipratropium and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, has anticholinergic effects, so ipratropium may add to dry mouth, constipation, urinary retention and blurred vision. The effect is generally modest at standard inhaled doses.
What this interaction means in plain words
Ipratropium and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects, especially in elderly patients or those with glaucoma. Lower the maprotiline dose or switch agents if symptoms are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Ipratropium with Maprotiline?
MediHelp rates the interaction as moderate. Ipratropium and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline, a tetracyclic antidepressant, has anticholinergic effects, so ipratropium may add to dry mouth, constipation, urinary retention and blurred vision. The effect is generally modest at standard inhaled doses.
How serious is the interaction between Ipratropium and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in elderly patients or those with glaucoma. Lower the maprotiline dose or switch agents if symptoms are troublesome.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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