Drug interactions
Ipratropium + Pilocarpine
Severity: Minor
Ipratropium and Pilocarpine: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and ipratropium is a muscarinic antagonist, so they may oppose each other's effects. The clinical relevance with inhaled ipratropium is likely small because systemic exposure is low.
What this interaction means in plain words
Ipratropium and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium belongs to Respiratory; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced pilocarpine effect (e.g., dry mouth relief) or reduced bronchodilation; no dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Pilocarpine Hydrochloride - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Ipratropium with Pilocarpine?
MediHelp rates the interaction as minor. Ipratropium and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pilocarpine is a muscarinic agonist and ipratropium is a muscarinic antagonist, so they may oppose each other's effects. The clinical relevance with inhaled ipratropium is likely small because systemic exposure is low.
How serious is the interaction between Ipratropium and Pilocarpine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pilocarpine effect (e.g., dry mouth relief) or reduced bronchodilation; no dose change is usually needed.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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