Drug interactions
Ipratropium + Tiotropium
Severity: Moderate
Ipratropium and Tiotropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled antimuscarinic bronchodilators, and combining them duplicates therapy and may increase anticholinergic effects such as dry mouth, urinary retention and glaucoma risk. The combination offers little added benefit.
What this interaction means in plain words
Ipratropium and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium belongs to Respiratory; Tiotropium belongs to Respiratory.
Why it happens
Duplicate muscarinic receptor antagonism with additive local and systemic anticholinergic effects.
What to do
Avoid routine concurrent use; stop ipratropium when tiotropium is started, using a short-acting beta-agonist for rescue instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Tiotropium
Frequently asked questions
Can I take Ipratropium with Tiotropium?
MediHelp rates the interaction as moderate. Ipratropium and Tiotropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled antimuscarinic bronchodilators, and combining them duplicates therapy and may increase anticholinergic effects such as dry mouth, urinary retention and glaucoma risk. The combination offers little added benefit.
How serious is the interaction between Ipratropium and Tiotropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; stop ipratropium when tiotropium is started, using a short-acting beta-agonist for rescue instead.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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