Drug interactions
Ipratropium + Umeclidinium-vilanterol
Severity: Moderate
Ipratropium and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium and ipratropium are both inhaled antimuscarinic bronchodilators, so using them together duplicates therapy. This increases the risk of anticholinergic effects such as dry mouth, urinary retention, constipation, and raised intraocular pressure, without a well-established added benefit.
What this interaction means in plain words
Ipratropium and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism from two anticholinergic agents.
What to do
Avoid routine concurrent use and stop ipratropium when the umeclidinium-containing inhaler is started. If used together, monitor for urinary retention, narrow-angle glaucoma symptoms and other anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ipratropium and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium and ipratropium are both inhaled antimuscarinic bronchodilators, so using them together duplicates therapy. This increases the risk of anticholinergic effects such as dry mouth, urinary retention, constipation, and raised intraocular pressure, without a well-established added benefit.
How serious is the interaction between Ipratropium and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use and stop ipratropium when the umeclidinium-containing inhaler is started. If used together, monitor for urinary retention, narrow-angle glaucoma symptoms and other anticholinergic effects.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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