Drug interactions
Ipratropium-salbutamol + Itraconazole
Severity: Moderate
Ipratropium-salbutamol and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can prolong the QT interval, and salbutamol may add to proarrhythmic risk through hypokalemia and tachycardia. Systemic exposure from inhaled salbutamol is low, so the risk is mainly in patients with other risk factors. Itraconazole may also modestly raise salbutamol exposure through CYP3A4/P-gp inhibition.
What this interaction means in plain words
Ipratropium-salbutamol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation and hypokalemia risk, with possible minor pharmacokinetic increase in salbutamol exposure.
What to do
Check potassium and magnesium and obtain a baseline ECG in patients with cardiac disease or other QT-prolonging drugs. Watch for palpitations or tremor and reduce salbutamol use if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Itraconazole?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can prolong the QT interval, and salbutamol may add to proarrhythmic risk through hypokalemia and tachycardia. Systemic exposure from inhaled salbutamol is low, so the risk is mainly in patients with other risk factors. Itraconazole may also modestly raise salbutamol exposure through CYP3A4/P-gp inhibition.
How serious is the interaction between Ipratropium-salbutamol and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and obtain a baseline ECG in patients with cardiac disease or other QT-prolonging drugs. Watch for palpitations or tremor and reduce salbutamol use if they occur.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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