Drug interactions
Ipratropium-salbutamol + Labetalol
Severity: Major
Ipratropium-salbutamol and Labetalol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta-2 receptors and can antagonize the bronchodilating effect of salbutamol, and may provoke bronchospasm in patients with asthma or COPD. The non-selective beta-blocking activity makes it a poor choice in reactive airway disease. Higher doses of salbutamol may be needed, with reduced effectiveness.
What this interaction means in plain words
Ipratropium-salbutamol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ipratropium-salbutamol belongs to Respiratory; Labetalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors by the non-selective beta-blocking activity of labetalol.
What to do
Avoid labetalol in patients with asthma or significant bronchospastic COPD and choose an alternative antihypertensive such as a calcium channel blocker. If unavoidable, monitor respiratory function closely and be prepared to escalate bronchodilator therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ipratropium-salbutamol
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Labetalol?
MediHelp rates the interaction as major. Ipratropium-salbutamol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol blocks beta-2 receptors and can antagonize the bronchodilating effect of salbutamol, and may provoke bronchospasm in patients with asthma or COPD. The non-selective beta-blocking activity makes it a poor choice in reactive airway disease. Higher doses of salbutamol may be needed, with reduced effectiveness.
How serious is the interaction between Ipratropium-salbutamol and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid labetalol in patients with asthma or significant bronchospastic COPD and choose an alternative antihypertensive such as a calcium channel blocker. If unavoidable, monitor respiratory function closely and be prepared to escalate bronchodilator therapy.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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