Drug interactions
Ipratropium-salbutamol + Mefloquine
Severity: Moderate
Ipratropium-salbutamol and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can cause QT changes and cardiac conduction abnormalities, and salbutamol may add risk through hypokalemia and tachycardia. At inhaled doses the added risk is small but relevant with other risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization, with beta-2 agonist-induced hypokalemia.
What to do
Correct potassium and magnesium and consider ECG monitoring in patients with cardiac disease or other QT-prolonging drugs. Consider an alternative antimalarial if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Mefloquine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can cause QT changes and cardiac conduction abnormalities, and salbutamol may add risk through hypokalemia and tachycardia. At inhaled doses the added risk is small but relevant with other risk factors.
How serious is the interaction between Ipratropium-salbutamol and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and consider ECG monitoring in patients with cardiac disease or other QT-prolonging drugs. Consider an alternative antimalarial if risk is high.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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