Drug interactions
Ipratropium-salbutamol + Moxifloxacin
Severity: Moderate
Ipratropium-salbutamol and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is a recognised QT-prolonging antibiotic, and salbutamol may add to this effect, especially at high doses. Hypokalemia from salbutamol increases the likelihood of torsades de pointes.
What this interaction means in plain words
Ipratropium-salbutamol and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia as a contributing factor.
What to do
Check potassium and magnesium and consider an ECG in patients with cardiac disease or other QT-prolonging drugs. Choose a non-QT-prolonging antibiotic if the patient is high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Moxifloxacin?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin is a recognised QT-prolonging antibiotic, and salbutamol may add to this effect, especially at high doses. Hypokalemia from salbutamol increases the likelihood of torsades de pointes.
How serious is the interaction between Ipratropium-salbutamol and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and consider an ECG in patients with cardiac disease or other QT-prolonging drugs. Choose a non-QT-prolonging antibiotic if the patient is high risk.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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