Drug interactions
Ipratropium-salbutamol + Osimertinib
Severity: Moderate
Ipratropium-salbutamol and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is associated with QT prolongation. Salbutamol, especially at high doses, may add to this through hypokalemia and increased heart rate.
What this interaction means in plain words
Ipratropium-salbutamol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Osimertinib belongs to Oncology.
Why it happens
Additive QT interval prolongation, with salbutamol-induced hypokalemia as a contributing factor.
What to do
Monitor ECG and electrolytes in patients with other QT risk factors. Correct hypokalemia and hypomagnesemia and avoid excessive salbutamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Osimertinib
Frequently asked questions
Can I take Ipratropium-salbutamol with Osimertinib?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is associated with QT prolongation. Salbutamol, especially at high doses, may add to this through hypokalemia and increased heart rate.
How serious is the interaction between Ipratropium-salbutamol and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with other QT risk factors. Correct hypokalemia and hypomagnesemia and avoid excessive salbutamol use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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