Drug interactions
Ipratropium-salbutamol + Perphenazine
Severity: Minor
Ipratropium-salbutamol and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic properties and can prolong QT, and salbutamol can add to QT effects and lower potassium at high doses. Systemic ipratropium exposure is low, so the anticholinergic contribution is small.
What this interaction means in plain words
Ipratropium-salbutamol and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium-salbutamol belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Weak additive anticholinergic effects and possible additive QT effects.
What to do
No routine changes needed; monitor ECG and potassium if high doses of salbutamol are used or other QT risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Perphenazine?
MediHelp rates the interaction as minor. Ipratropium-salbutamol and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has anticholinergic properties and can prolong QT, and salbutamol can add to QT effects and lower potassium at high doses. Systemic ipratropium exposure is low, so the anticholinergic contribution is small.
How serious is the interaction between Ipratropium-salbutamol and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine changes needed; monitor ECG and potassium if high doses of salbutamol are used or other QT risk factors exist.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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