Drug interactions
Ipratropium-salbutamol + Promethazine
Severity: Minor
Ipratropium-salbutamol and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is sedating and anticholinergic, so it may add to the antimuscarinic effects of ipratropium, although inhaled ipratropium has little systemic absorption. Promethazine can also thicken bronchial secretions.
What this interaction means in plain words
Ipratropium-salbutamol and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium-salbutamol belongs to Respiratory; Promethazine belongs to Respiratory.
Why it happens
Weak additive antimuscarinic effects.
What to do
No routine adjustment is needed; watch for dry mouth, urinary retention and sedation in elderly patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Promethazine?
MediHelp rates the interaction as minor. Ipratropium-salbutamol and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine is sedating and anticholinergic, so it may add to the antimuscarinic effects of ipratropium, although inhaled ipratropium has little systemic absorption. Promethazine can also thicken bronchial secretions.
How serious is the interaction between Ipratropium-salbutamol and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for dry mouth, urinary retention and sedation in elderly patients.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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