Drug interactions
Ipratropium-salbutamol + Ribociclib
Severity: Moderate
Ipratropium-salbutamol and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes concentration-dependent QT prolongation, and salbutamol may add to this effect, especially with hypokalemia. The combination raises the possibility of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Ipratropium-salbutamol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-agonist-induced potassium lowering as a contributing factor.
What to do
Monitor ECG and electrolytes as required for ribociclib, and correct potassium and magnesium before and during treatment. Limit salbutamol to the lowest effective dose and reassess if QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Ribociclib?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib causes concentration-dependent QT prolongation, and salbutamol may add to this effect, especially with hypokalemia. The combination raises the possibility of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Ipratropium-salbutamol and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes as required for ribociclib, and correct potassium and magnesium before and during treatment. Limit salbutamol to the lowest effective dose and reassess if QTc rises.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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