Drug interactions
Ipratropium-salbutamol + Tacrolimus
Severity: Moderate
Ipratropium-salbutamol and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval and cause electrolyte disturbances such as hyperkalemia or hypomagnesemia, and salbutamol may add to QT risk. The combination is mainly relevant with high doses or other risk factors.
What this interaction means in plain words
Ipratropium-salbutamol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation with electrolyte effects of both drugs.
What to do
Monitor ECG, potassium and magnesium in patients with additional QT risk factors, and keep salbutamol use to the minimum needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Tacrolimus?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval and cause electrolyte disturbances such as hyperkalemia or hypomagnesemia, and salbutamol may add to QT risk. The combination is mainly relevant with high doses or other risk factors.
How serious is the interaction between Ipratropium-salbutamol and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium in patients with additional QT risk factors, and keep salbutamol use to the minimum needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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