Drug interactions
Ipratropium-salbutamol + Vemurafenib
Severity: Moderate
Ipratropium-salbutamol and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way, and salbutamol may add to this through tachycardia and hypokalemia. The risk is greater with high doses or other predisposing factors.
What this interaction means in plain words
Ipratropium-salbutamol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Correct electrolyte abnormalities and monitor ECG in patients using salbutamol frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Vemurafenib
Frequently asked questions
Can I take Ipratropium-salbutamol with Vemurafenib?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QT interval in a concentration-dependent way, and salbutamol may add to this through tachycardia and hypokalemia. The risk is greater with high doses or other predisposing factors.
How serious is the interaction between Ipratropium-salbutamol and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolyte abnormalities and monitor ECG in patients using salbutamol frequently.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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