Drug interactions
Ipratropium-salbutamol + Voriconazole
Severity: Moderate
Ipratropium-salbutamol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can prolong the QT interval, and salbutamol can cause hypokalemia and tachycardia, which increase the risk of torsades de pointes. The risk is higher with high-dose or nebulised salbutamol and in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Ipratropium-salbutamol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and increased heart rate.
What to do
Correct potassium and magnesium before and during treatment, and obtain an ECG in patients with additional QT risk factors or frequent salbutamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Voriconazole?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can prolong the QT interval, and salbutamol can cause hypokalemia and tachycardia, which increase the risk of torsades de pointes. The risk is higher with high-dose or nebulised salbutamol and in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Ipratropium-salbutamol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during treatment, and obtain an ECG in patients with additional QT risk factors or frequent salbutamol use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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