Drug interactions
Ipratropium-salbutamol + Vorinostat
Severity: Moderate
Ipratropium-salbutamol and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation, and salbutamol can add to arrhythmia risk through tachycardia and hypokalemia. The concern is greater with high doses or electrolyte disturbances.
What this interaction means in plain words
Ipratropium-salbutamol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Vorinostat belongs to Oncology.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Monitor ECG, potassium and magnesium in patients with cardiac risk factors, and avoid excessive salbutamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Vorinostat?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation, and salbutamol can add to arrhythmia risk through tachycardia and hypokalemia. The concern is greater with high doses or electrolyte disturbances.
How serious is the interaction between Ipratropium-salbutamol and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium in patients with cardiac risk factors, and avoid excessive salbutamol use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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