Drug interactions
Irbesartan + Labetalol
Severity: Moderate
Irbesartan and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan lowers blood pressure and can raise serum potassium, so combined use with labetalol may cause additive hypotension. Hyperkalemia is more likely in renal impairment.
What this interaction means in plain words
Irbesartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with angiotensin receptor blockade reducing aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, serum potassium and renal function after starting or changing doses. Adjust therapy if hypotension or hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Labetalol?
MediHelp rates the interaction as moderate. Irbesartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan lowers blood pressure and can raise serum potassium, so combined use with labetalol may cause additive hypotension. Hyperkalemia is more likely in renal impairment.
How serious is the interaction between Irbesartan and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and renal function after starting or changing doses. Adjust therapy if hypotension or hyperkalemia occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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