Drug interactions
Irbesartan + Lonafarnib
Severity: Minor
Irbesartan and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, but irbesartan is not a CYP3A inhibitor. No meaningful rise in lonafarnib exposure is expected.
What this interaction means in plain words
Irbesartan and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
No established mechanism; irbesartan does not inhibit CYP3A4 to a relevant extent.
What to do
No dose adjustment needed; follow routine monitoring for lonafarnib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Irbesartan with Lonafarnib?
MediHelp rates the interaction as minor. Irbesartan and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, but irbesartan is not a CYP3A inhibitor. No meaningful rise in lonafarnib exposure is expected.
How serious is the interaction between Irbesartan and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; follow routine monitoring for lonafarnib adverse effects.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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