Drug interactions
Irbesartan + Lornoxicam
Severity: Moderate
Irbesartan and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can blunt the antihypertensive effect of irbesartan and, by reducing renal prostaglandins, impair kidney function and raise potassium. The risk of acute kidney injury is higher in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Irbesartan and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and potassium excretion, compounding angiotensin receptor blockade.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Irbesartan with Lornoxicam?
MediHelp rates the interaction as moderate. Irbesartan and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can blunt the antihypertensive effect of irbesartan and, by reducing renal prostaglandins, impair kidney function and raise potassium. The risk of acute kidney injury is higher in older, volume-depleted or renally impaired patients.
How serious is the interaction between Irbesartan and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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