Drug interactions
Irbesartan + Methylphenidate
Severity: Moderate
Irbesartan and Methylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate can raise blood pressure and heart rate and may reduce the control achieved with antihypertensives such as irbesartan. The effect is usually modest but relevant in patients with hypertension.
What this interaction means in plain words
Irbesartan and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Methylphenidate belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: sympathomimetic pressor effects of methylphenidate oppose the blood pressure lowering of angiotensin receptor blockade.
What to do
Monitor blood pressure after starting or adjusting methylphenidate and adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Irbesartan with Methylphenidate?
MediHelp rates the interaction as moderate. Irbesartan and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate can raise blood pressure and heart rate and may reduce the control achieved with antihypertensives such as irbesartan. The effect is usually modest but relevant in patients with hypertension.
How serious is the interaction between Irbesartan and Methylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or adjusting methylphenidate and adjust antihypertensive therapy if control worsens.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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