Drug interactions
Irbesartan + Metoprolol
Severity: Minor
Irbesartan and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs together lower blood pressure more than either alone, and the combination is often used deliberately. Irbesartan may raise serum potassium, whereas metoprolol has little effect. Irbesartan is contraindicated in pregnancy.
What this interaction means in plain words
Irbesartan and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects; ARB-related reduction of aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure and heart rate at initiation and dose changes. Check potassium and renal function periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Metoprolol?
MediHelp rates the interaction as minor. Irbesartan and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two drugs together lower blood pressure more than either alone, and the combination is often used deliberately. Irbesartan may raise serum potassium, whereas metoprolol has little effect. Irbesartan is contraindicated in pregnancy.
How serious is the interaction between Irbesartan and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at initiation and dose changes. Check potassium and renal function periodically.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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