Drug interactions
Irbesartan + Midazolam
Severity: Minor
Irbesartan and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan is metabolised by CYP2C9 and does not inhibit CYP3A4 in a meaningful way. No clinically significant interaction with midazolam is expected.
What this interaction means in plain words
Irbesartan and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Midazolam belongs to Central Nervous System.
Why it happens
No established mechanism.
What to do
No adjustment needed; monitor blood pressure during procedural sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Midazolam?
MediHelp rates the interaction as minor. Irbesartan and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irbesartan is metabolised by CYP2C9 and does not inhibit CYP3A4 in a meaningful way. No clinically significant interaction with midazolam is expected.
How serious is the interaction between Irbesartan and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor blood pressure during procedural sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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